Three-dimensional quantitative structure-activity relationships and docking studies of some structurally diverse flavonoids and design of new aldose reductase inhibitors
Aldose reductase (AR) plays an important role in k2 grateful dead skis the development of several long-term diabetic complications.Inhibition of AR activities is a strategy for controlling complications arising from chronic diabetes.Several AR inhibitors have been reported in the literature.Flavonoid type compounds are shown to have significant AR